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KMID : 1134820190480050509
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 5 p.509 ~ p.514
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Effects of Blueberry Ethanol Extract on Improvement of Constipation in an Animal Model Treated with Bifidobacterium bifidum
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Kim Ji-Won
An Yoen-Ju
Lee Jeong-Yoon
Jun Woo-Jin
Lee Yoo-Hyun
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Abstract
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We investigated the effects of 30% ethanol extract of blueberry (VC30) on improvement of constipation in an in vivo model treated with Bifidobacterium bifidum. The total polyphenol content of VC30 was 275.12±2.97 mg GAE/g and bacterial growth of B. bifidum was not affected by VC30 containing medium. Investigation of improvement of intestinal function, revealed that the gastrointestinal transit in Balb/c mice treated with B. bifidum and VC30 increased significantly compared to the control group (P<0.05). For improvement of constipation, VC30 was administered orally for seven days with B. bifidum to loperamide-induced SD rats. The amount of feces in VC30 groups (VC30 300 or 500 mg/kg BW with B. bifidum) was significantly higher than in the Lop group (loperamide and B. bifidum treated group) (P<0.05). These findings indicated that polyphenol-rich blueberry extract was a potent candidate to improve constipation.
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KEYWORD
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polyphenol, blueberry, constipation, loperamide, Bifidobacterium bifidum
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